A 25-year-old woman requires 2 units of Red Blood Cells. Which antibodies may cause a positive antibody screen?

In the context of blood banking, recognizing which antibodies can potentially cause a positive antibody screen is crucial for safe transfusion practices.

The correct choice indicates that anti-c and anti-E antibodies may cause a positive reaction on an antibody screen. Both of these antibodies are clinically significant and can be detected using standard serological techniques. Anti-c is part of the Rh blood group system, and its presence can lead to hemolytic transfusion reactions if not appropriately matched. Similarly, anti-E, another Rh antibody, can also react during compatibility testing and is significant in transfusion medicine.

The other combinations involve antibodies that either may not be clinically significant or are less commonly encountered in routine antibody screens. For instance, while anti-M might show up in some screenings, it is generally not associated with severe transfusion reactions compared to anti-c and anti-E. Understanding the significance of different antibodies helps ensure that patients receive the safest compatible blood products.