A patient who is group AB, Rh-negative needs 2 units of Fresh Frozen Plasma. Which of the following units of plasma would be most acceptable for transfusion?

For a patient who is group AB and Rh-negative requiring Fresh Frozen Plasma (FFP), the best choice is plasma from a group AB donor, even if the Rh factor is positive.

Group AB individuals are known as universal recipients for plasma transfusions because they possess both A and B antigens and do not have anti-A or anti-B antibodies in their plasma. This characteristic allows AB recipients to receive plasma from any blood group. While Rh compatibility is an important consideration, plasma does not contain the red blood cell component, which means that the presence of Rh-positive plasma will not create an adverse reaction in terms of antibodies against Rh factors. However, the offer of Rh-negative plasma is ideal if available, as it poses no risk of sensitization.

Choosing group AB plasma is the most compatible option for a patient with AB blood type, ensuring that the transfusion is safe and effective. Other group plasmas can still be used, but they carry risks of allergic reactions or immune responses based on the recipient's existing antibodies.