A temperature rise of 1C or more during a transfusion, without abnormal results, typically indicates which reaction?

A temperature rise of 1°C or more during a transfusion is commonly associated with a febrile reaction. This type of reaction is typically a non-hemolytic and is characterized by a rise in temperature due to the recipient's immune response to certain proteins in the donor blood, most often leukocytes. Febrile reactions usually occur when blood components containing white blood cells are transfused into a patient who has developed antibodies against these leukocyte antigens.

The absence of other abnormal findings, such as hemolysis or signs of an allergic response, further supports that the reaction is febrile in nature. Other reactions, such as circulatory overload, hemolytic reactions, and anaphylactic reactions, present with different clinical signs and symptoms, which further differentiate them from a febrile reaction. Therefore, a temperature increase of this magnitude, without other accompanying symptoms, aligns most clearly with a febrile transfusion reaction.