During storage, the concentration of 2,3-diphosphoglycerate (2,3-DPG) decreases in a unit of?

The concentration of 2,3-diphosphoglycerate (2,3-DPG) is particularly relevant in the context of red blood cells because 2,3-DPG plays a crucial role in regulating hemoglobin's affinity for oxygen. In stored red blood cells, the levels of 2,3-DPG progressively decline over time, particularly when the units are preserved under standard conditions (such as refrigeration).

This reduction can impact oxygen release to tissues; lower levels of 2,3-DPG lead to higher affinity of hemoglobin for oxygen, which results in decreased oxygen delivery to the tissues during transfusion. Therefore, understanding the dynamics of 2,3-DPG during storage helps transfusion medicine professionals predict the functional capacity of stored red blood cells.

In contrast, platelets, fresh frozen plasma, and cryoprecipitated AHF do not undergo similar depletions of 2,3-DPG. Platelets primarily concern themselves with clotting factors and their lifespan and functionality are affected differently. Fresh frozen plasma is mainly comprised of clotting factors and proteins, while cryoprecipitated AHF is specifically concentrated with fibrinogen and other clotting components. Therefore, these options do not exhibit the same