Hypotension, nausea, flushing, fever, and chills are symptoms of which transfusion reaction?

The symptoms of hypotension, nausea, flushing, fever, and chills are indicative of a hemolytic transfusion reaction, which primarily occurs due to an immune response against transfused red blood cells. This type of reaction typically arises when there is ABO incompatibility, leading to the destruction of the donor red blood cells by the recipient’s immune system.

In a hemolytic reaction, the release of cytokines and other inflammatory mediators can cause systemic symptoms such as fever and chills, as well as gastrointestinal distress that manifests as nausea. Hypotension may occur due to the shock-like state that results from the rapid hemolysis and the release of vasoactive substances, which can cause vascular dilation and lead to decreased blood pressure. Flushing can also be a result of the release of inflammatory mediators.

Recognizing these symptoms is critical for immediate intervention, as hemolytic reactions can lead to severe complications if not addressed promptly.