In warm autoimmune hemolytic anemia, autoantibodies are commonly associated with which blood group system?

In warm autoimmune hemolytic anemia (WAIHA), autoantibodies that are produced by the immune system typically target red blood cell antigens, leading to hemolysis. The most commonly associated blood group system with these autoantibodies is the Rh blood group system. In this condition, the body mistakenly recognizes its own red blood cells as foreign due to these autoantibodies, which primarily bind best at body temperature (typically around 37°C).

The Rh system encompasses a group of antigens, the most significant of which is the D antigen. In many cases of WAIHA, the autoantibodies are directed against this D antigen, resulting in increased destruction of Rh-positive red blood cells when Rh-negative blood is provided during a transfusion.

Other blood group systems listed, such as I, P, and Duffy, are associated with different types of antibody-mediated hemolysis but are less commonly linked to warm autoimmune hemolytic anemia. The I system is more often implicated in cold agglutinin disease, the P system is associated with infections and Paroxysmal Cold Hemoglobinuria, and the Duffy system is primarily involved in malaria susceptibility and not typically linked with warm autoimmune conditions. Therefore,