Leukocyte-Poor Red Blood Cells are most likely indicated for patients with a history of what?

Leukocyte-Poor Red Blood Cells are particularly indicated for patients with a history of febrile transfusion reactions. These reactions are often caused by the recipient's immune response to white blood cells that may be present in the transfused product. By using leukocyte-poor red blood cells, which have been filtered to remove most white blood cells, the risk of febrile reactions can be significantly reduced. This is particularly important for patients who have previously experienced such responses during or after transfusions, as it helps to ensure a safer transfusion experience.

The other options, while relevant to other aspects of transfusion medicine, do not specifically correlate with the need for leukocyte removal to prevent febrile reactions. Iron deficiency anemia, hemophilia A, and von Willebrand disease pertain to different underlying conditions or deficiencies that do not directly relate to the adverse effects caused by leukocytes in blood transfusions. Thus, the use of leukocyte-poor blood products is primarily geared towards managing and preventing febrile transfusion reactions in susceptible patients.