Rh immune globulin administration would not be indicated in an Rh-negative woman who has a:

The administration of Rh immune globulin (RhoGAM) is primarily indicated to prevent Rh sensitization in Rh-negative women who may be exposed to Rh-positive blood, such as during pregnancy or abortion. In the case of a woman with an anti-D titer of 1:4,096, her high titer suggests that she has already been sensitized to Rh-positive blood. This level of anti-D antibody means that she has a significant immune response against Rh-positive red blood cells. Consequently, administering Rh immune globulin would not provide any benefit in this situation since the sensitization has already occurred, and further prevention is not necessary or effective.

In contrast, during a first trimester abortion, the risks of Rh sensitization are present, but Rh immune globulin may be indicated depending on the circumstances. If the husband is Rh-positive, there is potential for the woman to be exposed to Rh antigens, which is why monitoring and possible administration of RhoGAM could be warranted. A positive direct antiglobulin test may indicate hemolytic disease or a reaction involving Rh incompatibility, further emphasizing the need for careful management, including possible Rh immune globulin administration. Therefore, it is the high anti-D titer that clearly indicates a