What increment of platelets/uL is expected to result from each single unit of Platelets transfused to a non-HLA-sensitized recipient?

When a single unit of platelets is transfused to a non-HLA-sensitized recipient, the expected increment in platelet count typically falls within the range of 5,000 to 10,000 platelets per microliter (uL). This range reflects the average response seen in patients who have not previously developed antibodies against human leukocyte antigens (HLA), which can complicate platelet transfusions.

The rationale behind this is based on studies measuring the post-transfusion platelet increment in populations that are HLA-sensitized versus those who are not. In non-sensitized patients, the transfused platelets are usually effective at raising the platelet count, leading to the anticipated increment.

For sensitized recipients, where antibodies may target the transfused platelets, the increment would be lower, hence the importance of knowing the sensitization status of the patient before predicting the exact response to platelet transfusion. The values above and below the correct answer represent either lower expected increments seen in specific clinical scenarios or higher increments that might occur in exceptional cases rather than the average expected increase in non-sensitized individuals.