What is the optimum storage temperature for Red Blood Cells, Frozen?

The optimum storage temperature for frozen red blood cells is indeed -80 °C. This temperature is critical for preserving the integrity of the red blood cells during long-term storage. At -80 °C, metabolic activity is halted, and the risk of ice crystal formation that can damage cell membranes is minimized.

The process of freezing red blood cells involves using cryoprotectants, like glycerol, which helps to protect the cells from damage during the freezing and thawing process. Storing at -80 °C ensures that these protective measures are fully effective and helps to maintain the cells in a viable state for future transfusions or research.

In comparison, temperatures like -20 °C or -12 °C are not low enough to provide the same level of preservation for frozen red blood cells. While 4 °C is commonly used for the storage of whole blood or red blood cells in a refrigerated state, it is not suitable for frozen storage as it allows for metabolic processes to continue, leading to cellular degradation. Therefore, -80 °C is the optimal choice for maintaining the long-term quality and viability of red blood cells when frozen.