What is the recommended storage temperature for Cryoprecipitated AHF?

Cryoprecipitated AHF (Antihemophilic Factor) is typically stored at a temperature of 4 °C. This temperature is crucial for maintaining the stability and efficacy of the clotting factors present in the cryoprecipitate, particularly factor VIII and fibrinogen. At this temperature, the integrity of these proteins is preserved, which is essential for their function in coagulation.

While 1-6 °C could potentially maintain the product, the more precise recommendation is specifically at 4 °C to ensure optimal preservation. Storing cryoprecipitate at temperatures significantly below freezing, such as -20 °C, would not be appropriate since it can lead to the denaturation of proteins or changes in the matrix that could impair function upon thawing. Room temperature storage could also lead to degradation of the factors and a risk for bacterial growth, which compromises safety and efficacy for transfusion purposes. Therefore, 4 °C is the recommended condition for effective storage of Cryoprecipitated AHF.