What percentage of the general Caucasian donor population would be compatible with a group O, Rh-negative patient with anti-D and anti-K?

To determine the percentage of the general Caucasian donor population that would be compatible with a group O, Rh-negative patient who has anti-D and anti-K antibodies, it is important to understand the implications of these antibodies on blood transfusion compatibility.

A group O, Rh-negative patient has no A or B antigens on their red blood cells and, therefore, can receive blood only from donors who are also group O and Rh-negative. Additionally, the presence of anti-D means this patient cannot receive Rh-positive blood due to the risk of hemolytic reactions.

The anti-K antibody indicates that the patient has developed an immune response against the K antigen, which is part of the Kell blood group system. Consequently, the patient can only receive blood from donors who are not K-positive. The prevalence of K antigen in the donor population is about 9%, meaning that approximately 91% of Caucasians are K-negative and would be compatible in terms of this antibody.

Thus, for a group O, Rh-negative patient with both anti-D and anti-K, the applicable donor pool is significantly narrowed. The compatibility criteria point to a very small percentage of the Caucasian donor population fitting these specifications.

Taking into account the approximate prevalence of group O blood (