What type of transfusion reaction is minimized by using only male donors for plasma transfusions?

The choice of minimizing transfusion reactions by using only male donors for plasma transfusions is primarily linked to the prevention of Transfusion-Related Acute Lung Injury (TRALI). TRALI is a serious and potentially life-threatening reaction that can occur after the transfusion of blood products, especially plasma-rich products.

The association between TRALI and the presence of antibodies in female plasma is significant. Female donors, particularly those who have been pregnant, are at a higher risk of having developed anti-HLA (human leukocyte antigen) and anti-granulocyte antibodies. These antibodies can react with the recipient's leukocytes, triggering an acute inflammatory response in the lungs, leading to TRALI.

By restricting plasma donations to male donors, the likelihood of these antibodies being present in the transfused plasma is reduced. Therefore, the potential for inducing TRALI is minimized. This practice is a preventive measure taken to enhance patient safety during transfusions.

Other types of reactions, such as allergic reactions, hemolytic reactions, and TACO (transfusion-associated circulatory overload), may occur due to various factors but are not specifically mitigated by the gender of the blood donor in the same way that TRALI is. Thus, using male donors for plasma is a