Which blood group system's antibodies can often lead to allergic transfusion reactions?

The Kidd blood group system is associated with antibodies that can lead to allergic transfusion reactions. These antibodies, primarily anti-Jka and anti-Jkb, have a unique characteristic in that they can become undetectable after the initial sensitization event. This means that a patient who has previously formed an antibody may not necessarily test positive for it at the time of a crossmatch, leading to potential complications during transfusions.

Once a transfusion containing the corresponding antigen is given, the recipient's immune system may mount a reaction due to the presence of these antibodies, resulting in allergic reactions that range from mild to severe. The Kidd antibodies can also facilitate hemolytic transfusion reactions if not properly matched, underscoring the importance of comprehensive blood typing and antibody screening prior to transfusions.

In contrast, while the other blood group systems mentioned also have their significance, they are not commonly associated with allergic reactions to the same extent as the Kidd system. Understanding the clinical implications of different blood group antibodies helps ensure patient safety and effective transfusion practices.