Which of the following blood components contains the most Factor VIII concentration relative to volume?

Cryoprecipitated AHF (Antihemophilic Factor) is the blood component that contains the highest concentration of Factor VIII relative to volume. This component is derived from fresh frozen plasma through a process of thawing and then spinning in a centrifuge to separate the precipitate, which is rich in clotting factors, including Factor VIII.

During the preparation of cryoprecipitate, factors such as fibrinogen, Factor VIII, and von Willebrand factor are concentrated. The result is a small volume product that boasts a very high concentration of these factors, making it particularly useful in treating conditions such as hemophilia A, where Factor VIII deficiency is a concern.

Fresh frozen plasma contains a wider range of plasma proteins, including clotting factors and other components, but the concentration of Factor VIII is not as high relative to the total volume of the plasma. Similarly, single-donor plasma and platelets do not have the same concentration of Factor VIII due to the nature of their processing and their respective contents.

Therefore, cryoprecipitated AHF is the most effective source for delivering concentrated Factor VIII, which is why it is the correct answer.