Which parameter is most closely monitored to identify transfusion-related acute lung injury (TRALI)?

Oxygen saturation levels are the most closely monitored parameter for identifying transfusion-related acute lung injury (TRALI). TRALI is a serious complication that can occur within six hours of receiving a blood transfusion, characterized by acute respiratory distress and non-cardiogenic pulmonary edema. One of the hallmark signs of TRALI is a rapid decline in oxygen saturation due to the impaired gas exchange in the lungs.

Monitoring oxygen saturation levels helps clinicians detect the onset of respiratory distress early, allowing for prompt intervention. The drop in oxygen saturation is indicative of the pulmonary issues that can arise from TRALI, making it a critical parameter in patient assessment following a transfusion.

Other parameters, while important in monitoring overall patient condition, do not specifically point to the respiratory aspects of TRALI as clearly as oxygen saturation. Changes in blood pressure or temperature may signify a different set of complications and are not specifically indicative of lung injury related to transfusions. Similarly, plasma levels of bilirubin are more relevant to hemolytic reactions rather than TRALI. Therefore, oxygen saturation levels are crucial for recognizing and managing this potentially life-threatening condition effectively.